Role overview
*Job Title: Research Scientist, Cell Biology – T Cell Biology
Duration: 12 months extendable contract
Location: Santa Monica, CA 90404
Type of Position: Only on W2 basis
Description
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Discovery Research is seeking a highly motivated Research Scientist to lead characterization studies that address product efficacy and safety.
The successful candidate will report to a Director and will be expected to independently design and perform experiments, organize and analyze results, and communicate and present findings in team meetings
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What you'll work on
Execution of cell-based functional and biochemical assays to select candidate molecules for clinical development or support combination strategies to enhance T cell product potency and safety
Experimental design aimed to address basic tumor immunology aspects related to the immunosuppressive tumor microenvironment
Genetic/biochemical manipulation of T cells and evaluation of impact on T cell function
Analyze, organize and communicate results at different research and cross-functional meetings
Plan and effectively execute experiments based on strategy, project timelines and goals
Analyze and present scientific results to the project team in addition to cross-functional and cross-site audiences
Document experimental results to enable subsequent clinical studies and patent applications
May serve as a core team member or leader on a project team
Work effectively with other functions (including Process Development, Translational Medicine, Clinical Development) to ensure alignment cross-functionally
Coordinate tasks across multiple projects, demonstrating prioritization and planning
May mentor junior team members and supervise the work of a research team including, but not limited to, organizing and prioritizing laboratory work and review of generated experimental results
What we're looking for
Experience designing and developing primary immune cell assays using key immune cell populations
Hands-on expertise in T-cell functional characterization assays including in vitro cxytotoxicity, proliferation, cytokine/chemokine measurements, cell signaling, activation, differentiation and exhaustion
Proficient in cell culture aseptic technique
Proficient in multi-parameter flow cytometry (panel design, sample acquisition, data processing) and data analysis (FACSDiva, FlowJo, GraphPad Prism, Excel)
Experience with MSD/ELISA and/or Luminex
Ph.D. degree in biology-related field (immunology, cellular and/or tumor biology or a closely related field)
A strong background in cancer immunotherapy and human immunology, experience working with engineered T cells strongly preferred
Demonstrated independence in experimental design, data analysis, interpretation, and presentation