Brain Ponderings podcast with Dr. Mark Mattson
Brain Ponderings podcast with Dr. Mark Mattson

Alex Kwan: Cutting-Edge Technologies Reveal How Psilocybin Rewires the Brain's Neural Networks

27 January 2026 1:00:02 Mark Mattson

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About this episode

The rapid psychedelic effects of the mushroom chemical psilocybin and its long-lasting mood-elevating effects are remarkable. While psilocybin and other psychedelics activate the serotonin 5HT2A receptor the nature of the functional and structural changes responsible for the dramatic effects of psychedelics on perception, mood, and cognition are unknown. In this episode Cornell University Professor Alex Kwan talks about very recent research in his laboratory showing that psilocybin triggers long-lasting changes in the structure of certain neural networks in the brain that may explain the neuropsychological effects of psychedelics.

LINKS

Kwan lab at Cornell

https://alexkwanlab.org/

Review article in Nature Reviews Neuroscience:

file:///Users/markmattson/Downloads/s41583-024-00876-0%20(1).pdf

Article in Nature:

file:///Users/markmattson/Downloads/s41586-025-08813-6%20(2).pdf

Article in CELL:

https://www.cell.com/action/showPdf?pii=S0092-8674%2825%2901305-4

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